We study innate and adaptive immunity to #viruses and #cancer. #COVID19 #immunology #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleEMD @YaleSPH.
What do #COVID19 reinfection cases mean? Here is a commentary I wrote on this topic for @TheLancetInfDis.
Recovery from #SARSCoV2 infection does not guarantee protection from reinfection, disease or becoming infectious again. But a good vaccine can.
“It is important to keep in mind that the reinfection cases in general are being picked up because of symptoms and are biased towards detection of symptomatic cases.” Most will be mild or asymptomatic. twitter.com/VirusesImmunit…
Daniel Bastardo Blanco, PhD
Tue Oct 13
“[R]einfection cases tell us that we cannot rely on immunity acquired by natural infection to confer herd immunity; not only is this strategy lethal for many but also it is not effective.” Insightful commentary by @VirusesImmunity buff.ly/312tZhf
I think these cases of reinfection will be exceptions. The initial illness was unusually prolonged, and the second illness developed very soon after. Need to know more about the immune system in such cases. twitter.com/dbastardo27/st…
I've worked on all of science, from B cells to T cells.
An important point by @VirusesImmunity on the Nevada patient:
'The patient had positive antibodies after the reinfection, but whether he had pre-existing antibody after the first infection is unknown'
'Because of the wide range of serological testing platforms used across the globe, it's impossible to compare results from one assay to another. For example, ab reactivity to nucleocapsid ptn indicates previous exposure to SARS-CoV-2 but not whether anti-spike abs are present'
Circles back to the key point we need to know the immune correlate of protection for Covid-19:
"The key goal for the future is to ascertain the level and specificity of antibody to spike protein at the time of reinfection, to determine immune correlate of protection." twitter.com/CyrilPedia/sta…
Reinfection by @VirusesImmunity
Reinfections happen. There may be bias towards symptomatic, and questions still to be answered.
Rirst reinfection resulting in death also resulting today - although in the context of an immunodeficiency state
Yale Immunologist Akiko Iwasaki on reinfection and why going for natural herd immunity won’t work: ‘this strategy...lethal for many but also it is not effective. Herd immunity requires safe and effective vaccines’
Spectacular summary by @VirusesImmunity on SARS-CoV-2 reinfections
Some key points:
- we are missing many reinfection bc testing limitations
- Infection need not confer durable immunity
- no evidence of altered immunocompetence in cases