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Oct 16

Immunity
Treatments
Remdesivir and interferon fall flat in WHO’s megastudy of COVID-19 treatments
Solidarity fails to find mortality benefits in four treatments—but the global trial itself wins praise
https://www.sciencemag.org/news/2020/10/remdesivir-and-interferon-fall-flat-who-s-megastudy-covid-19-treatments
Jon Cohen @sciencecohen - Fri Oct 16
Gilead's Remdesivir doesn't save lives. So says a large, multi-country study run by WHO's Solidarity trial network. An indepth look at the study by @kakape also notes that Gilead just cut a $1B deal with Europe for the drug. sciencemag.org/news/2020/10/r…
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Expert replies & quotes
Soumya Swaminathan @doctorsoumya - Fri Oct 16
The power of global scientific collaboration & #Solidarity @DrTedros @WHO @JeremyFarrar @MoHFW_INDIA @ICMRDELHI @pahowho @WHOWPRO @WHOSEARO @WHOAFRO @WHO_Europe @WHOEMRO @JNkengasong @jarottingen @IreneNorstedt sciencemag.org/news/2020/10/r…
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Martin Enserink @martinenserink - Fri Oct 16
Remdesivir and interferon don't reduce COVID-19 mortality, @WHO's Solidarity trial finds. The silver lining is that the global megastudy (11,000 patients in 30 countries) worked and produced solid results fast. bit.ly/3k2zTGs
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Dr. Ali Khan @UNMC_DrKhan - Sat Oct 17
Regardless of the disappointing initial results, the @WHO Solidarity trail is a major win for the world to quickly access promising #COVID19 therapeutics. Over 1300 doctors, 400 hospitals, and 30 countries. Now a platform for newer options like antibodies! sciencemag.org/news/2020/10/r…
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Kai Kupferschmidt @kakape - Fri Oct 16
“This trial doesn’t help remdesivir, that’s for sure,” says @EricTopol. “It's not a dead duck as much as hydroxychloroquine, but it certainly is not the hope that was initially signaled.” sciencemag.org/news/2020/10/r…
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Kai Kupferschmidt @kakape - Fri Oct 16
“It's disappointing that none of the four have come out and shown a difference in mortality, but it does show why you need big trials,” says @JeremyFarrar. My story on @WHO’s Solidarity trial results is out (slightly delayed by having food poisoning 🤷‍♂️) sciencemag.org/news/2020/10/r…
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Ash Paul @pash22 - Fri Oct 16
Remdesivir and interferon fall flat in @WHO ’s megastudy of COVID-19 treatments sciencemag.org/news/2020/10/r…
Martin Enserink @martinenserink - Fri Oct 16
“This trial doesn’t help remdesivir, that’s for sure,” @EricTopol says. “It's not a dead duck as much as hydroxychloroquine, but it certainly is not the hope that was initially signaled.” bit.ly/3k2zTGs
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Mark Hoofnagle @MarkHoofnagle - Fri Oct 16
We should be livid with Gilead. They’ve played us for billions. sciencemag.org/news/2020/10/r…
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