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Oct 15

Treatments
Vaccines
Immunity
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results
BACKGROUND WHO expert groups recommended mortality trials in hospitalized COVID-19 of four re-purposed antiviral drugs. METHODS Study drugs were Remdesivir, Hydroxychloroquine, Lopinavir...
https://www.medrxiv.org/content/10.1101/2020.10.15.20209817v1
Eric Topol @EricTopol - Thu Oct 15
The SOLIDARITY randomized trial of 4 repurposed drugs in 11, 266 hospitalized patients with #COVID19: HCQ, Remdesivir, Interferon, Lopinavir (each vs placebo) All without effect on survival or secondary endpoints medrxiv.org/content/10.110… pic.twitter.com/WDW2N3M3B9
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Adam Kucharski @AdamJKucharski - Fri Oct 16
"Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay." medrxiv.org/content/10.110…
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Jeremy Farrar @JeremyFarrar - Fri Oct 16
Not the result anyone hoped for. But so important to have robust, definitive data from large randomised trials. Huge credit to everyone involved in @WHO coordinated Solidarity Trial medrxiv.org/content/10.110…
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Harlan Krumholz @hmkyale - Thu Oct 15
This is blockbuster from @WHO: 'Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens have little or no effect on hospitalized COVID-19, as indicated by mortality, initiation of ventilation and duration of hospital stay. @medrxivpreprint medrxiv.org/content/10.110… pic.twitter.com/daOAMVW62u
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ID Journal Club @IDJClub - Sun Oct 18
October 26. 9 pm ET. #IDJClub does WHO's Solidarity Trial. medrxiv.org/content/10.110… pic.twitter.com/piiku1zpzg
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Michael Fralick @FralickMike - Thu Oct 15
.#SOLIDARITY results are out as preprint in @medrxivpreprint ! N=11,000+ hospitalized with #COVID, randomized to remdesivir, hydroxychloroquine, lopinavir-ritonavir, interferon B1a vs standard of care. 1/4 medrxiv.org/content/10.110…
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Ilan Schwartz MD PhD @GermHunterMD - Thu Oct 15
Solidarity preliminary report now published (as pre-print) Clearly zero overall 28 d mortality benefit to remdesivir “This absolutely excludes the suggestion that Remdesivir can prevent a substantial fraction of all deaths” H/t @DrToddLee medrxiv.org/content/10.110… pic.twitter.com/10Q5B8rmGi
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ɪᴀɴ ᴍ. ᴍᴀᴄᴋᴀʏ, ᴘʜᴅ 🦠🤧🧬🥼🦟🧻 @MackayIM - Thu Oct 15
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results medrxiv.org/content/10.110…
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Spooky Health Nerd @GidMK - Thu Oct 15
WHO results from the massive SOLIDARITY trial are out The findings are pretty bleak. No discernible benefit for hydroxychloroquine, lopinavir/ritonavir, remdesivir, or interferon on any endpoint (death, ventilation, discharge) medrxiv.org/content/10.110… pic.twitter.com/cXnX15rueK
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Marc Mendelson @SouthAfricanASP - Fri Oct 16
#Dexamethasone & equivalent steroids. remain the only therapeutic to reduce mortality from #COVID19 as ⁦@WHO⁩ SOLIDARITY trial results indicate no effect of #Remdesivir and interferon on reducing death rates medrxiv.org/content/10.110…
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Peter Collignon @CollignonPeter - Thu Oct 15
Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay. medrxiv.org/content/10.110…
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Dr Gaetan Burgio, MD, PhD. @GaetanBurgio - Fri Oct 16
Who said the #hydroxychloroquine treatment for #COVID19 is innocuous and no risk? Here is the results from the SOLIDARITY trial (@WHO) showing the probability effect on cardiac death at 14 and 28 days post treatment medrxiv.org/content/10.110… pic.twitter.com/Rfu2qsJc4O
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Jake Dunning @OutbreakJake - Fri Oct 16
*PRE-PRINT not yet peer reviewed* SOLIDARITY trial findings. What now for remdesivir? medrxiv.org/content/10.110…
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Todd Lee @DrToddLee - Thu Oct 15
Solidarity trial preprint is live medrxiv.org/content/10.110…
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Antibiotic Steward🆔 Bassam Ghanem @ABsteward - Thu Oct 15
🔥Breaking news🔥 #SOLIDARITY @WHO 405 hospitals, 30 countries, n=11k Interim results indicate Rremdesivir,HCQ,lopinavir/ritonavir&interferon regimens appeared to have little or no effect on 28-day mortality /the in-hospital course of #COVID19 medrxiv.org/content/10.110… pic.twitter.com/l8B0dONWWc
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Richard Sever Ⓤ @cshperspectives - Fri Oct 16
Big WHO study shows little/no effect of remdesivir, lopinavir, ritonavir or interferon in COVID-19 medrxiv.org/content/10.110…
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John-Arne Røttingen @jarottingen - Fri Oct 16
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results | Unfortunately no effects of Remdesivir, hydroxychloroquine, Kaletra or interferon ⁦@doctorsoumya⁩ ⁦@WHO⁩ medrxiv.org/content/10.110…
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Ash Paul @pash22 - Fri Oct 16
Repurposed antiviral drugs for COVID-19; interim @WHO SOLIDARITY trial results medrxiv.org/content/10.110…
Isaac Bogoch @BogochIsaac - Thu Oct 15
Results of the WHO SOLIDARITY trial: 30 countries & 11,266 adults with #COVID19 randomized to Remdesivir, Hydroxychloroquine, Lopinavir, Interferon or no study drug. None of these regimens had any real benefit on mortality or length of hospital stay. bit.ly/3lQIht7 pic.twitter.com/GNhKSK9o1s
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Carlos Arturo Álvarez Moreno @AlvarezMorenoC - Thu Oct 15
Primeros resultados del estudio Solidaridad. El primer análisis con 11.000 pacientes. Infortunadamente ninguno de los medicamentos probados mostró impacto en mortalidad Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results medrxiv.org/content/10.110…
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Huet Sylvestre @HuetSylvestre - Fri Oct 16
#COVID__19 L'argument des fanas de l'#HCQ "c'est pour que Big Pharma vende le Remdesivir" tombe à l'eau : l'essai Solidarity de l'OMS montre que #HCQ, #remdesivir , #lopinavir, #ritonavir, #Interferon-β1a... aucun ne marche contre le Sars-Cov-2. medrxiv.org/content/10.110… pic.twitter.com/w5YSswwxUg
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