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Nov 17

Immunity
Immunological memory to SARS-CoV-2 assessed for greater than six months after infection
Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the pandemic. We analyzed multiple compartments of...
https://www.biorxiv.org/content/10.1101/2020.11.15.383323v1
Apoorva Mandavilli @apoorva_nyc - Tue Nov 17
THE GOOD NEWS: Immunity to the coronavirus might last years, maybe even decades, according to a new study — the most hopeful look yet at this issue. 1/x nytimes.com/2020/11/17/hea…
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Expert replies & quotes
Shane Crotty @profshanecrotty - Tue Nov 17
1/ Our pre-print on immune memory to SARS-CoV-2 is out today. To our knowledge, this is the largest such study for any acute infection. The upshot is that there is substantial immune memory after COVID-19. Lots of stuff in this manuscript. biorxiv.org/content/10.110…
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Greg Dore @GregDore2 - Tue Nov 17
Evaluation of multiple immune aspects—neutralizing antibody, memory B cells, T cell (CD4+, CD8+)—provides reassuring evidence of high-level responses to 6 months, w/ potential to persist much longer. Good news. ⁦@apoorva_nyc⁩ biorxiv.org/content/10.110… nytimes.com/2020/11/17/hea…
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Jon Cohen @sciencecohen - Tue Nov 17
This graph made me smile. It's from @profshanecrotty, @SetteLab preprint: biorxiv.org/content/10.110… Antibodies to the Achille's heel of SARS-CoV-2--spike's receptor binding domain--persist and even rise as far as 8 months out. Sure, immunity wanes. It does this, too. pic.twitter.com/zgiaCiq5YR
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Ashraful Haque @DrAshHaque - Wed Nov 18
Immunological memory to SARS-CoV-2 assessed for greater than six months after infection biorxiv.org/content/10.110…
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Chaim M Lebovits @LebovitsM - Tue Nov 17
biorxiv.org/content/10.110…
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Steven Riley @SRileyIDD - Wed Nov 18
"Very few published data sets compare antigen-specific antibody, B cell, CD8+T cell, and CD4+T cell memory to an acute viral infection in the same individuals." This one does! Wow. biorxiv.org/content/10.110…
Daniel Kraft, MD @daniel_kraft - Wed Nov 18
Blood samples from recovered #COVID19 patients suggest a powerful, long-lasting immune response. Pre-print study biorxiv.org/content/10.110… nytimes.com/2020/11/17/hea…
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Danny Altmann @Daltmann10 - Tue Nov 17
Immunological memory to SARS-CoV-2 assessed for greater than six months after infection | bioRxiv biorxiv.org/content/10.110…
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Florian Krammer @florian_krammer - Tue Nov 17
Lots of great West Coast COVID-19 immunology with some East Coast sprinkled in. Thanks for including @VivianaSimonLab and me in this nice work @profshanecrotty and @SetteLab! biorxiv.org/content/10.110…
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