1/ Yes, I said it.
“That amount of memory would likely prevent the vast majority of people from getting hospitalized disease—severe disease—for many years.”
We collected immunological memory data, and this is the conclusion the data point to. No promises—only time will tell. twitter.com/apoorva_nyc/st…
"Eight months after infection, most people who have recovered [from #COVID19] still have enough immune cells to fend off the virus and prevent illness."
Article below & Preprint here: bit.ly/2UDkbGFtwitter.com/apoorva_nyc/st…
Vaccine Scientist. Immune system scientist. Professor, La Jolla Institute for Immunology.
1/ Our pre-print on immune memory to SARS-CoV-2 is out today. To our knowledge, this is the largest such study for any acute infection.
The upshot is that there is substantial immune memory after COVID-19.
Lots of stuff in this manuscript.
Kirby Institute: infectious diseases; hepatitis C; hepatitis B; health for people who use drugs
Evaluation of multiple immune aspects—neutralizing antibody, memory B cells, T cell (CD4+, CD8+)—provides reassuring evidence of high-level responses to 6 months, w/ potential to persist much longer. Good news. @apoorva_nyc
Science magazine staff writer on infectious diseases, outbreaks, immunology, vaccines, global health, genomics, CRISPR, primates, surfing. Views mine.
This graph made me smile. It's from @profshanecrotty, @SetteLab preprint: biorxiv.org/content/10.110…
Antibodies to the Achille's heel of SARS-CoV-2--spike's receptor binding domain--persist and even rise as far as 8 months out. Sure, immunity wanes. It does this, too. pic.twitter.com/zgiaCiq5YR
Husband, dad and infectious disease scientist. Lucky to work with great people at universities, in governments and in NGOs... but all views here are my own.
"Very few published data sets compare antigen-specific antibody, B cell, CD8+T cell, and CD4+T cell memory to an acute viral infection in the same individuals."
This one does! Wow.
Viruses, viruses, viruses and vaccines
Professor at the Department of Microbiology
Icahn School of Medicine at Mount Sinai
Lots of great West Coast COVID-19 immunology with some East Coast sprinkled in. Thanks for including @VivianaSimonLab and me in this nice work @profshanecrotty and @SetteLab! biorxiv.org/content/10.110…