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@apoorva_nyc If you look at work from @SalomonJA and @AshTuite in @AnnalsofIM helps explain the mentality. If done well, should not have a significant delay in 2nd doses for the majority of people. acpjournals.org/doi/10.7326/m2…

@jabarocas @apoorva_nyc @SalomonJA @AshTuite @AnnalsofIM .@katherineWu

@jabarocas @apoorva_nyc @AshTuite @AnnalsofIM Yes - this shift should take place mostly behind the scenes, with the result being more available supply at state and local levels. As we modeled in our paper, the aim is really to get more people to first doses early and second doses on time, *not* to alter the dosing schedule.

@SalomonJA @jabarocas @apoorva_nyc @AshTuite @AnnalsofIM .@katherineWu

@jabarocas @SalomonJA @AshTuite @AnnalsofIM I don't disagree, especially if they can invoke the defense production act and move quickly. I just mean from a public perspective, there are so many mixed messages between OWS, FDA and now Biden admin

@apoorva_nyc @SalomonJA @AshTuite @AnnalsofIM That's the key. Defense production act. Rapid mobilization of vaccines. On the job training. Etc. RESOURCES!

Big questions with this news: -will manufacturing, allocation keep up enough to ensure those who received a 1st dose receive the 2nd dose on time? -will state vaccine distribution efforts be able to absorb the influx and administer all these new doses equitably, efficiently?

2/3: if we’re that desperate for #COVID19 vaccines, the emphasis needs to be on accelerating the two adenovirus vaccines and particle vaccines

3/3: Also our recombinant protein COVID19 vaccine is now being scaled to 1.2 billion doses in India 🇮🇳 we could also bring that in if we had the support of OpWarpSpeed and BARDA.

Finally no matter what, we need to fix our vaccine infrastructure and turn it into a high throughput system

Apologies for the typos

@bethlinas It shouldn't. @SalomonJA and @AshTuite released this paper last week that nicely details how this might work. If done as researchers outline. @AnnalsofIM acpjournals.org/doi/10.7326/m2…

@jabarocas @SalomonJA @AshTuite @AnnalsofIM Awesome. Thank you for sharing - I knew there was a manuscript but couldn’t remember where I saw it! Great news

@jabarocas @SalomonJA @AshTuite @AnnalsofIM Great news, let’s do it! “Under a steady vaccine supply of 6 million doses per week, the flexible strategy would result in an additional 23% to 29% of #COVID19 cases averted compared with the fixed strategy”