physician-scientist, author, editor
We thought B.1.1.7's increased infectiousness was due to higher viral load. New data from @NBA players and staff, with frequent sampling, suggests it's related to delayed clearance, longer duration of infections
dash.harvard.edu/handle/1/37366… @StephenKissler @yhgrad and colleagues pic.twitter.com/T352viTcxp
Dr. Angela Rasmussen
Wed Feb 17
Interesting. A longer interval of contagiousness has always been a possible explanation for increased variant transmissibility.
But this is also n=7, so this is by no means settled, nor are other hypothetical mechanisms (more shedding, more infectivity, more stability) excluded. twitter.com/EricTopol/stat…
Really interesting observation of viral trajectories in 7 people with B.1.1.7 variant infection. Not higher peak viral loads, but slower upslope and clearance than non-B.1.1.7 -- hence greater duration of infection. Could this explain increased contagiousness? twitter.com/yhgrad/status/…
What makes B117 spread more quickly?
This study finds B117 infections are ~5 days *longer* (avg. 13d vs 8d for WT), though they currently have only n=7 fully sampled B117 viral load profiles.
Nevertheless, this may represent another critical puzzle piece of B117. twitter.com/yhgrad/status/…
Senior Scientist/Epidemiologist @SickKidsNews @SickKidsGlobal. Associate Prof @UofTMedicine @UofT_DLSPH. Views are my own.🇨🇦 🇧🇷
Variant B.1.1.7 may cause longer infections with similar peak viral loads to non-B.1.1.7 SARS-CoV-2. This may explain its increased transmissibility. It may also require rethinking isolation duration, no? dash.harvard.edu/handle/1/37366…
Infections in people with B.1.1.7 lasted an average of 13.3 days, compared with 8.2 days with other variants.
B.1.1.7 may be more easily transmitted due to longer infection and more opportunity to infect others, suggesting a need for longer quarantine. bit.ly/3qUhE9F
Aaron Richterman, MD
Sun Feb 21
infectious diseases, health equity @PennMedicine. prev @BrighamWomens @GlobalHealthMGH. “His horoscopes were especially popular because they were often right”
Regular sampling required to understand viral load dynamics of CoV2, as in this study of B1117, finding longer (not ⬆️) VL peak. As others have said this may explain ⬆️ infectiousness. More impt to me —prevention strategies effective before prob still work