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Feb 19

Immunity
Vaccines
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
The results of this primary analysis of two doses of ChAdOx1 nCoV-19 were consistent with those seen in the interim analysis of the trials and confirm that the vaccine is efficacious, with results...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00432-3/abstract
Ashish K. Jha, MD, MPH @ashishkjha - Sun Feb 21
Pooled analysis of 4 Oxford/AZ trials out @TheLancet Key results Among vaccinated, still no hospitalizations/deaths from COVID Modeling suggests that waiting 90 days for 2nd dose improves protection Findings support UK's first dose first approach thelancet.com/journals/lance…
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Eric Topol @EricTopol - Fri Feb 19
New exploratory analysis with Oxford/Astra Zeneca vaccine suggest that a more prolonged interval to 2nd dose, up to 3 months, is good for the immune response and efficacy thelancet.com/journals/lance… Just out @TheLancet pic.twitter.com/xtQkA5Og6u
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The Lancet @TheLancet - Fri Feb 19
NEW—Post-hoc exploratory analyses suggest 3-month interval between doses of Oxford #COVID19 #vaccine results in higher efficacy than 6-week interval, with first dose offering 76% protection in the 3 months between doses. hubs.li/H0GVc0G0 pic.twitter.com/S3V07aV8Ri
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thelonevirologist @thelonevirologi - Sat Feb 20
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials thelancet.com/journals/lance…
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The Lancet Microbe @LancetMicrobe - Sat Feb 20
New in ⁦@TheLancet⁩> Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of #ChAdOx1 nCoV-19 (#AZD1222) #vaccine: a pooled analysis of four randomised trials #COVID19 thelancet.com/journals/lance…
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Pramesh CS @cspramesh - Fri Feb 19
Pooled analysis of 4 RCTs shows higher efficacy when the Oxford-AZ vaccine doses were spaced 12 weeks apart than 6 weeks apart. Posthoc analysis, but compelling nevertheless given the magnitude of difference 81% vs 55% thelancet.com/journals/lance…
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Neelika Malavige @GMalavige - Mon Feb 22
thelancet.com/journals/lance…
Dr Zoë Hyde @DrZoeHyde - Sat Feb 20
Further AZ results are published. The most important endpoint is essentially unchanged. Efficacy against symptomatic infection (2 standard doses) is 63%. Post-hoc analyses suggest increased efficacy with a larger dose interval. 6 wk: 55% >=12 wk: 81% thelancet.com/journals/lance… pic.twitter.com/tpFzOePBbc
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