And very worrying long-term consequences even for those under 65 years of age. Brace up Ontario, this will cost a fortune. Much more expensive than testing, tracing and isolation, sick days, safe schools... pic.twitter.com/uZxnT9WYCJ
The volume of the issues is staggering and will be highly consequential to productivity and the wellbeing of the workforce. It is also extremely worrisome to think about the children whose parents will struggle with these neuro-psychiatric issues.
A quick back of the envelope calculation suggests that of the accumulated infections until now in ON, there are 70,000 ppl with anxiety disorders, 55,000 with mood disorders, 7,500 strokes, 11,000 people with neurological issues plus 18,000 people with insomnias.
virology; public health microbiology; global pathogen surveillance; preparedness and respons; syndromic diagnostics, human animal interface
The more we know, the less we know: 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. Shows increased rates of a range of neuropsychiatric disorders following COVID thelancet.com/journals/lanps…
Senior Lecturer @QMUL Epidemiology, statistical genetics, machine learning. Intersectional feminist. Advocating for a better culture in academia. All views mine
Important study out from @TheLancetPsych on neurological & psychiatric manifestations across 236,379 people with 6 months follow up after COVID-19 in the US- examined using electronic health records.
What did it find?
Important to note first that the study only included survivors- so people who had survived for at least 6 months following infection were included.
Several neurological and psychiatric outcomes were examined in electronic health record data from health-care facilities.
Healthcare facilities data were collected from including primary care facilities, hospitals, specialist units, ICUs. It's unclear from the study how representative these are of infection across the general population (i.e. who would have ended up in the study if infected)
In the full study, *1 in 3* people received a neurological or psychiatric diagnosis at 6 months. This was 32% among those not hospitalised, 39% for patients hospitalised and 46·42% for those admitted to ITU. pic.twitter.com/wTsxfdUpHk
The most common of these were mood & anxiety disorders.
To examine how these compared with other illness, the study investigators also compared the cohort with patients who had a flu or respiratory illness diagnosis, but were SARS-CoV-2 negative during the same period.
As underlying risk factors for disease can be different, patients with COVID-19 were matched to those in the control group for age, sex, ethnicity, obesity, hypertension, and several other underlying conditions to try and make the groups comparable in terms of underlying risk.
The study found significantly increased risk for stroke (both thrombotic and haemorrhagic), dementia, parkinsonism, and mood, anxiety and psychotic disorders, even among non-hospitalised pateients. Risk appeared to increase among those hospitalised & admitted to ITU. pic.twitter.com/hci086rTlL
This is an important study, and appears to support the occurrence of long-term neuro-psychiatric illness among those with COVID-19. It supports several studies of long COVID which also show long term neuro-cognitive symptoms persisting frequently.
Given the known neuroinvasive potential of SARS-CoV-2, & possible links with neuro-psychiatric conditions, this should be an area of urgent research & once again provide a clear warning that COVID-19 is not the flu & should be considered an illness with serious long-term impact.
Limitations: As this is observational, despite extensive matching between cases and controls there may be factors that were not matched for, and while risk of certain outcomes appears to be increased, causality is hard to establish with this evidence alone, as the authors state.
Sorry, forgot to mention- one aspect of the study that particularly concerns me is that the increased risk of neuro-psychiatric conditions doesn't flatten out at any point during the 6 month period, but differences in risk continue to persist at least until 6 months, as seen here pic.twitter.com/IMv0ctB34Z
This suggests that we need even longer term follow up studies to examine long term risk among people infected with SARS-CoV-2, as increased risk may persist for longer than previously thought - another argument for not only focusing on death as outcomes in public health policy.
ID Epi/emerg mgmt▪️Sr Dir SpecialPathogens @NYCHealthSystem▪️Faculty @TheNETEC▪️Fellow @BelferCenter ▪️COVIDTaskforce @FAScientists▪️Featured #Pandemic @Netflix
“A study of more than 230,000 COVID patients finds that, within six months of getting COVID, 34% of them experienced a neurological or psychiatric disorder; 13% of them were diagnosed with such conditions for the first time.” thelancet.com/journals/lanps…
Epidemiologist, professor at a College of Public Health, author of The Next Pandemic, retired Asst. Surgeon General. Views are my own. he/him/his
#LongCovid Large quarter million person study. About a third of #COVID19 patients at 6 months report psychiatric or neurological diagnosis - higher that other respiratory illness. Again, death is not the only adverse outcome of infections.
1/3 GET VACCINATED. This Lancet study has some caveats (retrospective) but neurological and psychiatric diseases post Covid are now documented in multiple studies. There is strong evidence for long term effects— this is not “just the flu”
physician-scientist, author, editor
Largest study of neurologic and mental health impact of covid at 6 months @TheLancetPsych today among >230,000 patients, compared with same N w/ respiratory tract/flu infections
1 in 3 affected
(#nottheflu) by @MaximeTaquet and colleagues @UniofOxford thelancet.com/journals/lanps…pic.twitter.com/HWLkdMpn0k
I've worked on all of science, from B cells to T cells.
'Our study provides evidence for substantial neurological and psychiatric morbidity in the 6 months after COVID-19 infection. Risks were greatest in, but not limited to, patients who had severe COVID-19.'
Infectious disease medical epidemiologist. Global health research, policy and programs. All views and posts are my own. “Salus populi suprema lex esto.”
Memo to the #vaccine hesitant: 34% of #COVID19 survivors received a diagnosis for a #neurological or #psychological condition within six months of infection; 13% were new diagnoses. thelancet.com/journals/lanps…