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May 01

Transmission
Limited within-host diversity and tight transmission bottlenecks limit SARS-CoV-2 evolution in acutely infected individuals
The recent emergence of divergent SARS-CoV-2 lineages has raised concerns about the role of selection within individual hosts in propagating novel variants. Of particular concern are variants...
https://www.biorxiv.org/content/10.1101/2021.04.30.440988v1
Katarina Braun @KATarinambraun - Sat May 01
New preprint 📢 We deep seq’d #SARSCoV2 and found within-host diversity is limited and rarely transmitted & transmission bottlenecks are narrow → slows the pace of #VOC emergence in *acute* infxs. We need to 👀 carefully at long-term infxs. 🧵 1/12 ⬇️ go.wisc.edu/dlm7zd
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